LONG-TERM EXPOSURE TO SMS-201-995 INHIBITS PROLIFERATION AND CALCITONIN RELEASE IN NEOPLASTIC C-CELLS

Authors
MEKONNEN Y RAUE F ZINK A ZIEGLER R
Citation
Y. Mekonnen et al., LONG-TERM EXPOSURE TO SMS-201-995 INHIBITS PROLIFERATION AND CALCITONIN RELEASE IN NEOPLASTIC C-CELLS, Hormone and Metabolic Research, 25(10), 1993, pp. 528-531
Citations number
22
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Hormone and Metabolic Research → ACNP
ISSN journal
00185043
Volume
25
Issue
10
Year of publication
1993
Pages
528 - 531
Database
ISI
SICI code
0018-5043(1993)25:10<528:LETSIP>2.0.ZU;2-J
Abstract
The effect of the long-acting somatostatin analogue SMS 201-995 on cel lular proliferation and calcitonin production was examined in rMTC 6-2 3 cells. A dose-dependent inhibition of calcitonin release and cellula r calcitonin content was obtained in cells exposed to SMS 201-995 for 72 hrs. The dose-dependent antiproliferative effect of SMS 201-995 (10 (-8)-10(-6) M) was significant after 72 hrs of exposure. SMS 201-995 h as an inhibitory effect on calcitonin secretion and synthesis as well as on the growth of C-cells.