F. Arreola et al., EFFECT OF ZINC TREATMENT ON SERUM THYROID-HORMONES IN UREMIC PATIENTSUNDER PERITONEAL-DIALYSIS, Hormone and Metabolic Research, 25(10), 1993, pp. 539-542
In order to evaluate the effect of zinc (Zn) deficiency on thyroid abn
ormalities in chronic renal failure, a Zn supplement (100 mg/day, p.o.
) was given for four weeks to eight uremic patients under peritoneal d
ialysis. Zn supplementation increased plasma levels of TSH (5.8 +/- 0.
7 to 7.4 +/- 0.7 mU/l, p < 0.02), T4 (61.6 +/- 3.9 to 93.9 +/- 6.2 nmo
l/l, p < 0.01), T3 (1.31 +/- 0.14 to 1.70 +/- 0.18 nmol/l, p < 0.01) a
nd Zn (7.23 +/- 0.45 to 12.27 +/- 0.76 mumol/l, p < 0.01). A close cor
relation was found between changes in plasma levels of Zn and changes
in TSH (r = 0.82), T4 (r = 0.55) and T3 (r = 0.64), suggesting that Zn
deficiency may play a role in the biosynthesis or release of hormones
of the hypothalamic-pituitary-thyroid axis in chronic renal failure.