SYNTHESIS AND BIOLOGICAL-ACTIVITY OF PLATINUM-GROUP METAL-COMPLEXES OF O-VANILLIN THIOSEMICARBAZONES

o-Vanillin-(4-methylthiosemicarbazone), o-Vanillin-(4-phenylthiosemica rbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and s tudied for their antibacterial, antifungal and amoebicidal activity in vitro. The platinum group metal chelates exibited significant activit y against a wide spectrum of microorganisms at different concentration s. The Pt(II) and Ru(III) chelates derived from o-vanillin-(4-phenylth iosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the compounds in mice infected with Pl asmodium berghei indicated that cures were attainable at dose levels o f 40-160 mg/kg but with toxic death prevalence at higher dose levels.