DOES PHOSPHOGLUCOISOMERASE DISPLAY ANOMERIC SPECIFICITY OR SELECTIVITY TOWARDS ALPHA-D-GLUCOSE 6-PHOSPHATE - AN ASSESSMENT BY 2-DIMENSIONALPHASE-SENSITIVE P-31 EXCHANGE SPECTROSCOPY (EXSY) NMR

Authors
KAYSER F BIESEMANS M WILLEM R MALAISSELAGAE F MALAISSE WJ
Citation
F. Kayser et al., DOES PHOSPHOGLUCOISOMERASE DISPLAY ANOMERIC SPECIFICITY OR SELECTIVITY TOWARDS ALPHA-D-GLUCOSE 6-PHOSPHATE - AN ASSESSMENT BY 2-DIMENSIONALPHASE-SENSITIVE P-31 EXCHANGE SPECTROSCOPY (EXSY) NMR, Biochemical journal, 295, 1993, pp. 607-609
Citations number
16
Categorie Soggetti
Biology
Journal title
Biochemical journal → ACNP
ISSN journal
02646021
Volume
295
Year of publication
1993
Part
2
Pages
607 - 609
Database
ISI
SICI code
0264-6021(1993)295:<607:DPDASO>2.0.ZU;2-R
Abstract
The study by two-dimensional phase-sensitive P-31 exchange spectroscop y (EXSY) n.m.r. of hexose 6-phosphates interconversion in the reaction catalysed by yeast phosphoglucoisomerase reveals that the enzyme disp lays anomeric selectivity rather than specificity, towards alpha-D-glu cose 6-phosphate. Indeed, beta-D-glucose 6-phosphate participates for about 20% to the total and direct conversion of the aldohexose into ox ohexose ester.