THE 39-KILODALTON OUTER-MEMBRANE PROTEIN OF PROTEUS-MIRABILIS IS AN OMPA PROTEIN AND MITOGEN FOR MURINE B-LYMPHOCYTES

Authors
KORN A KROLL HP BERGER HP KAHLER A HESSLER R BRAUBURGER J MULLER KP NIXDORFF K
Citation
A. Korn et al., THE 39-KILODALTON OUTER-MEMBRANE PROTEIN OF PROTEUS-MIRABILIS IS AN OMPA PROTEIN AND MITOGEN FOR MURINE B-LYMPHOCYTES, Infection and immunity, 61(11), 1993, pp. 4915-4918
Citations number
25
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
11
Year of publication
1993
Pages
4915 - 4918
Database
ISI
SICI code
0019-9567(1993)61:11<4915:T3OPOP>2.0.ZU;2-E
Abstract
Partial amino acid sequence analysis of a major outer membrane protein of Proteus mirabilis (39-kDa protein) indicates that it is an OmpA pr otein. The mitogenic activities of the 39-kDa protein for murine lymph ocytes were also investigated with T lymphocytes isolated by passing s pleen cells over columns of nylon wool fiber and B lymphocytes obtaine d by treating spleen cells with monoclonal antibodies to Thy1 plus com plement. The 39-kDa protein showed little activity in stimulating T ce lls to proliferate but was strongly mitogenic for B cells.