FAILURE OF PULMONARY CLEARANCE OF RHODOCOCCUS-EQUI INFECTION IN CD4-LYMPHOCYTE-DEFICIENT TRANSGENIC MICE( T)

Authors
KANALY ST HINES SA PALMER GH
Citation
St. Kanaly et al., FAILURE OF PULMONARY CLEARANCE OF RHODOCOCCUS-EQUI INFECTION IN CD4-LYMPHOCYTE-DEFICIENT TRANSGENIC MICE( T), Infection and immunity, 61(11), 1993, pp. 4929-4932
Citations number
24
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
11
Year of publication
1993
Pages
4929 - 4932
Database
ISI
SICI code
0019-9567(1993)61:11<4929:FOPCOR>2.0.ZU;2-R
Abstract
Pulmonary clearance of Rhudococcus equi requires functional T lymphocy tes. In this study, CD8+ T-lymphocyte-deficient transgenic mice cleare d virulent R. equi from the lungs while infection in CD4+ T-lymphocyte -deficient transgenic mice persisted. Although both CD4+ and CD8+ T ce lls function early in pulmonary defense against R. equi, clearance is dependent on CD4+ T lymphocytes.