INTERLEUKIN-10 PROTECTS MICE AGAINST STAPHYLOCOCCAL-ENTEROTOXIN B-INDUCED LETHAL SHOCK

Authors
BEAN AGD FREIBERG RA ANDRADE S MENON S ZLOTNIK A
Citation
Agd. Bean et al., INTERLEUKIN-10 PROTECTS MICE AGAINST STAPHYLOCOCCAL-ENTEROTOXIN B-INDUCED LETHAL SHOCK, Infection and immunity, 61(11), 1993, pp. 4937-4939
Citations number
22
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
11
Year of publication
1993
Pages
4937 - 4939
Database
ISI
SICI code
0019-9567(1993)61:11<4937:IPMASB>2.0.ZU;2-#
Abstract
We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Tr eatment of mice with IL-10 prevented the death of mice injected with S EB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in viv o.