A SYSTEMATIC STUDY ON THE CHEMICAL-STABILITY OF THE NOVEL INDOLOQUINONE ANTITUMOR AGENT EO9

Authors
DEVRIES JD WINKELHORST J UNDERBERG WJM HENRAR REC BEIJNEN JH
Citation
Jd. Devries et al., A SYSTEMATIC STUDY ON THE CHEMICAL-STABILITY OF THE NOVEL INDOLOQUINONE ANTITUMOR AGENT EO9, International journal of pharmaceutics, 100(1-3), 1993, pp. 181-188
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
100
Issue
1-3
Year of publication
1993
Pages
181 - 188
Database
ISI
SICI code
0378-5173(1993)100:1-3<181:ASSOTC>2.0.ZU;2-F
Abstract
The chemical stability of the new anticancer drug EO9 in aqueous solut ion has been investigated utilizing a stability-indicating reversed-ph ase high-performance liquid chromatographic assay with ultraviolet det ection and ultraviolet spectrophotometry. The degradation kinetics of EO9 have been studied as a function of pH, buffer composition, ionic s trength and temperature. A pH-rate profile, using rate constants extra polated to zero buffer concentration, was constructed demonstrating th at EO9 is most stable in the pH region 8-9. The degradation mechanism of EO9 in aqueous solution is discussed.