SIMULTANEOUS QUANTITATIVE-DETERMINATION OF SALBUTAMOL SULFATE AND BROMHEXINE HYDROCHLORIDE IN DRUG PREPARATIONS BY DIFFERENCE SPECTROPHOTOMETRY

A difference spectrophotometric procedure has been developed for the s imultaneous determination of salbutamol sulfate (SS) and bromhexine hy drochloride (BH) in tablet preparations. The method comprised the meas urements of the absorbance of a solution of the drug mixture in pH 2.0 buffer solution relative to that of an equimolar solution in 0.1 N me thanolic NaOH at wavelengths of 310 and 280 nm. The presence of identi cal isosbestic points for pure drug solutions and sample solutions ind icated the non-interference of excipients in the absorption at these w avelengths. Compliance with Beer's law was achieved in the concentrati on range of 0-100 mug/ml for SS and 0-200 mug/ml for BH at these wavel engths.