PREDICTIVE VALUE OF TISSUE-PLASMINOGEN ACTIVATOR MASS CONCENTRATION ON LONG-TERM MORTALITY IN PATIENTS WITH CORONARY-ARTERY DISEASE - A 7-YEAR FOLLOW-UP
Jh. Jansson et al., PREDICTIVE VALUE OF TISSUE-PLASMINOGEN ACTIVATOR MASS CONCENTRATION ON LONG-TERM MORTALITY IN PATIENTS WITH CORONARY-ARTERY DISEASE - A 7-YEAR FOLLOW-UP, Circulation, 88(5), 1993, pp. 2030-2034
Background. The fibrinolytic system is part of the defense against thr
ombotic and cardiovascular events, but so far no study has shown that
clinical measurements of fibrinolytic key components such as tissue pl
asminogen activator (t-PA) or plasminogen activator inhibitor type 1 (
PAI-1) have any predictive value beyond 3 years. Methods and Results.
In 1983 through 1985, 213 consecutive patients with angina pectoris an
d angiographically verified coronary artery disease were sampled, and
the mass concentration of t-PA and the activity of PAI-1 were measured
in citrated plasma samples. At a mean follow-up time of 7 years, the
all-cause mortality was checked. No patient was lost to follow-up. The
data were analyzed by Cox regression, and t-PA mass concentration was
found to be the only laboratory risk factor significantly related to
mortality in all patients (P<.022) and also in the major subgroup (78%
of all patients) subjected to coronary bypass surgery (P<.027). In th
e latter subgroup, body mass index was also related to mortality. Conc
lusions. An increased mass concentration of t-PA is a new risk factor
of long-term mortality in patients with angina pectoris and coronary a
rtery stenosis. This paradoxical effect probably reflects increased t-
PA levels attributable to enzyme inhibitor complex formation in subjec
ts with increased plasma levels of t-PA inhibitors.