SYNTHESIS OF 11-[H-3]-ARTEETHER, AN EXPERIMENTAL ANTIMALARIAL DRUG

Authors
PU YM ZIFFER H
Citation
Ym. Pu et H. Ziffer, SYNTHESIS OF 11-[H-3]-ARTEETHER, AN EXPERIMENTAL ANTIMALARIAL DRUG, Journal of labelled compounds & radiopharmaceuticals, 33(11), 1993, pp. 1013-1018
Citations number
14
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
11
Year of publication
1993
Pages
1013 - 1018
Database
ISI
SICI code
0362-4803(1993)33:11<1013:SO1AEA>2.0.ZU;2-W
Abstract
The triphenylphosphine hydrobromide-catalyzed addition of a proton fro m ethanol to anhydrodihydroartemisinin (5) has been employed for the s ynthesis of 2 and 4. Use of 1.5 equivalents of EtO2H or EtO3H yielded 11-[H-2]- or 11-[H-3]-beta-arteether as the major product.