TC-99M AND DEUTERIUM-LABELED RADIODIAGNOSTICS - COMPARISON OF HMPAO WITH CYTECTRENE DERIVATIVES OF CYCLIC AMINES

Authors
WENZEL M KLINGE C SAIDI M
Citation
M. Wenzel et al., TC-99M AND DEUTERIUM-LABELED RADIODIAGNOSTICS - COMPARISON OF HMPAO WITH CYTECTRENE DERIVATIVES OF CYCLIC AMINES, Journal of labelled compounds & radiopharmaceuticals, 33(11), 1993, pp. 1039-1051
Citations number
11
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
11
Year of publication
1993
Pages
1039 - 1051
Database
ISI
SICI code
0362-4803(1993)33:11<1039:TADR-C>2.0.ZU;2-7
Abstract
HMPAO-d2 and Deuterium labelled esters of Cytectrenecarbonic ester wit h alcohols of cyclic amines were synthesized and additional labelled w ith Tc-99m. The organ distribution in rats showed a higher brain uptak e of the cytectrene ester than HMPAO with a far higher Tc-99m concentr ation ratio brain/blood. The deuterated compounds showed a lower Tc-99 m concentration in blood, but no higher uptake in brain.