INCREASED LEVELS OF TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 IN BRONCHOALVEOLAR LAVAGE FLUIDS FROM PIGS INFECTED WITH MYCOPLASMA-HYOPNEUMONIAE

Authors
ASAI T OKADA M ONO M IRISAWA T MORI Y YOKOMIZO Y SATO S
Citation
T. Asai et al., INCREASED LEVELS OF TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 IN BRONCHOALVEOLAR LAVAGE FLUIDS FROM PIGS INFECTED WITH MYCOPLASMA-HYOPNEUMONIAE, Veterinary immunology and immunopathology, 38(3-4), 1993, pp. 253-260
Citations number
22
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
38
Issue
3-4
Year of publication
1993
Pages
253 - 260
Database
ISI
SICI code
0165-2427(1993)38:3-4<253:ILOTAI>2.0.ZU;2-8
Abstract
We examined the levels of tumor necrosis factor (TNF)-alpha and interl eukin-1 (IL-1) in bronchoalveolar lavage fluids (BALF) from pigs exper imentally infected with Mycoplasma hyopneumoniae using biological assa ys with WEHI-164 cells and D10.G4.1 cells, respectively. Increased TNF -alpha and IL-1 in BALF were found in infected pigs with gross and/or microscopic lesions. A time-course study suggested TNF-alpha and IL-1 to be persistently elevated in infected pigs. Their presence in BALF w ould thus appear to be associated with the development of pneumonic le sions in M. hyopneumoniae infected pigs.