Authors
Citation
C. Kinnon et al., X-LINKED AGAMMAGLOBULINEMIA - GENE CLONING AND FUTURE-PROSPECTS, Immunology today, 14(11), 1993, pp. 554-558
Citations number
40
Categorie Soggetti
Immunology
Journal title
ISSN journal
01675699
Volume
14
Issue
11
Year of publication
1993
Pages
554 - 558
Database
ISI
SICI code
0167-5699(1993)14:11<554:XA-GCA>2.0.ZU;2-4
Abstract
The btk gene has recently been identified as the causative gene in X-l
inked agammaglobulinemia (XLA). This has opened up many new possibilit
ies for the treatment. of this B-cell immunodeficiency. Christine Kinn
on and colleagues review the high degree of sequence of homology of bt
k to the non-receptor tyrosine kinases and speculate on putative roles
for this gene in B-cell development.