PEPTIDE-BOND FORMATION VIA AN INTRAMOLECULAR REARRANGEMENT

Authors
WIJKMANS JCHM VANBOOM JH BLOEMHOFF W
Citation
Jchm. Wijkmans et al., PEPTIDE-BOND FORMATION VIA AN INTRAMOLECULAR REARRANGEMENT, Tetrahedron letters, 34(44), 1993, pp. 7123-7126
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
44
Year of publication
1993
Pages
7123 - 7126
Database
ISI
SICI code
0040-4039(1993)34:44<7123:PFVAIR>2.0.ZU;2-Q
Abstract
Intramolecular peptide synthesis could be achieved using tetrahydropht halazine (1) as template. Peptide bond formation proceeded via the N-a cyl-N'-alpha-aminoacylhydrazine-rearrangement. The feasibility of the approach is illustrated by the synthesis of the protected tripeptide Z -Val-Gly-Ala-OMe (8).