LIVING-RELATED LIVER-TRANSPLANTATION ACROSS ABO BLOOD-GROUPS WITH FK506 AND OKT3

In living related liver transplantation (LRLT), the use of graft liver s across ABO blood groups is unavoidable since the organ donor is usua lly one of the recipient's parents. This report presents our initial e xperiences with LRLT, focusing on ABO-incompatible cases. From June 19 90 to May 1992, we successfully performed a series of 34 LRLT on child ren (15 males and 19 females) ranging in age from 7 months to 15 years . Overall recipient survival rates were 90% (25/28) in elective LRLT a nd 50% (3/6) in emergency LRLT. These cases were classified into three groups: ABO blood group-identical (n = 21), compatible (n = 10), and incompatible (n = 3). The immunosuppressive regimen consisted of FK506 and low-dose steroids in the first two groups. In the incompatible ca ses, exchange transfusion was performed to decrease anti-A and/or -B a ntibody titers before LRLT, and prophylactic OKT3 was added to FK506 a nd steroids after LRLT. No significant difference in recipient and gra ft survival was observed among the groups. In the identical group, no rejection episodes have been observed thus far. Rejection occurred in two out of the ten compatible cases. Among the incompatible cases, one recipient had mild rejection and was treated. The remaining two recip ients have had no rejection episodes thus far. Although all three reci pients had cytomegalovitus (CMV) infection, they were successfully tre ated with gancyclovir, and no lethal infection has developed in any of these cases. The present results suggest that graft livers from livin g related donors across ABO blood groups can function well with FK506, low-dose steroids, and prophylactic OKT3 without causing lethal compl ications.