TRANSITION-METAL COMPLEXES AS CATALYSTS OF ACTIVE OXYGEN SPECIES FORMATION IN AUTOOXIDATION REACTIONS .2. OXIDATIVE-DEGRADATION OF NUCLEIC-ACIDS BY COBALT AND IRON PHTHALOCYANINE COMPLEXES

Co- and Fe-phthalocyanine complexes with cationic and anionic substitu ents in the macroligand, which are effective in autooxidation of ascor bic acid in aqueous solutions, are studied in the reaction of oxidativ e cleavage of nucleic acids. It was shown for the first time that wate r-soluble, metal-phthalocyanine complexes can cleave nucleic acids in the reaction of dark conjugated autooxidation of ascorbic acid. Fe-oct akis(pyridinio-methyl)phthalocyanine chloride is the most efficient in oxidative degradation of RNA target, and Co- and Fe-phthalocyanine ca tionic complexes are the most efficient in oxidative degradation of DN As. Using the radical traps, it was shown that the oxidative degradati on of nucleic acids is caused by OH-radicals.