The diagnosis of migraine headache in children and adolescents is comp
lex and not well understood. This study was conducted to compare diagn
ostic rates, using various criteria for pediatric migraine, and specif
ic symptom characteristics in a sample of children referred for care t
o a specialized pediatric headache clinic. A structured interview was
used at the patient's initial assessment visit to elicit symptom patte
rns and therapies attempted for headache. Clinical diagnoses were base
d on consensus agreement reached by a multidisciplinary team. Statisti
cally derived diagnostic rates based on International Headache Society
(IHS), Prensky, Vahlquist and our own criteria were significantly low
er than clinical diagnostic rates. IHS diagnostic rates were different
ially distributed as a function of race, but no other effects were fou
nd for demographic variables on diagnostic rates. Specific symptom pat
terns, however, varied as a function of race, gender and age of the ch
ild. The results underscore the need for comprehensive, developmentall
y based models of the evolution of migraine headache as a foundation f
or future research and the further development of clinically sensitive
diagnostic criteria for pediatric migraine.