COMPARISON BETWEEN CELLULOSE AND AMYLOSE TRIS(3,5-DIMETHYLPHENYLCARBAMATE) CHIRAL STATIONARY PHASES FOR ENANTIOMERIC SEPARATION OF 17 AMIDOTETRALINS

Direct enantiomeric separations of 17 chiral amidotetralins by means o f high performance liquid chromatography were performed on stationary phases composed of tris(3,5-dimethylphenylcarbamate) derivatives of ce llulose and amylose, coated on silica gel. The enantiomers of 15 out o f 17 amidotetralins were resolved with a resolution of more than 1.5 b y at least one of the chiral stationary phases. The stationary phases showed complementary results with regard to the separation of the amid otetralins, that is, pairs that did not separate on the cellulose-type column were well separated on the amylose-type column, and vice versa . There was no significant correlation between the chromatographic pro perties of the chiral stationary phases. (C) 1993 Wiley-Liss, Inc.