PAPILLOMAVIRUS DNA TYPING ANALYSIS IN CONDYLOMA ACUMINATUM PATIENTS AND THEIR CONSORTS

The present study demonstrated human papillomavirus (HPV) infection by means of an in situ HPV DNA hybridization screening test (BIOHIT) in 8 male patients with genital condyloma acuminatum, their asymptomatic female consorts and 6 female patients with vulval condyloma acuminatum . The investigations revealed that all but one of the female consorts were infected by HPV but did not show any clinical sign of papillomavi rus infection. HPV DNA typing analyses with the most common HPVs prese nt in the genital tract (HPV 6, 11, 16, 18, 31 and 33) revealed the sa me HPV types in the consorts as found in their partners. (HPV 6 and/or 11 were detected in 4 pairs, HPV 18 and 31 in one pair each, and HPV 18/31 and 16/31 double infections in one pair each.) All cytological s pecimens of female patients with condyloma acuminatum were HPV-infecte d, the most frequent type being HPV 31. In the one patient with vulval condyloma acuminatum and carcinoma epidermoides cornescens, the ''hig h-risk'' HPV 18 was identified in both condyloma and carcinoma tissues .