ACANTHOSIS NIGRICANS AND BILE-DUCT MALIGNANCY

A case of acanthosis nigricans associated with a metastatic adenocarci noma is presented. To our knowledge this is the first one reported in the literature. The primary tumour is unknown, but it is presumably a cholangiocarcinoma. The skin changes preceded the detection of maligna ncy by 2 years, during which the skin lesions progressed though the pa tient was still in good health. If malignant acanthosis nigricans is s uspected and the underlying malignancy cannot be found at the initial screening, repeated screenings are necessary because of the time facto r.