ANTIMONIAL TREATMENT OF HAMSTERS INFECTED WITH LEISHMANIA (VIANNIA) PANAMENSIS - ASSESSMENT OF PARASITOLOGICAL CURE WITH DIFFERENT THERAPEUTIC SCHEDULES
Bl. Travi et al., ANTIMONIAL TREATMENT OF HAMSTERS INFECTED WITH LEISHMANIA (VIANNIA) PANAMENSIS - ASSESSMENT OF PARASITOLOGICAL CURE WITH DIFFERENT THERAPEUTIC SCHEDULES, Transactions of the Royal Society of Tropical Medicine and Hygiene, 87(5), 1993, pp. 567-569
Citations number
17
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
The objective of the study was to establish the effective dose and rou
te of administration of Glucantime(R) for treating hamsters infected w
ith Leishmania (Viannia) panamensis and to use this model to test new
treatment regimens to attain clinical and parasitological cure. In the
first experiments animals were inoculated subcutaneously in the hind
foot with 5 x 10(6) promastigotes of L. panamensis (HOM/COL/84/1099) f
rom a 6 d culture. One month after inoculation, Glucantime(R) was admi
nistered intramuscularly (i.m.) at 20, 40 or 60 mg/kg/d for 20 d to gr
oups of hamsters. Only 60 mg/kg/d resulted in both clinical improvemen
t and parasite elimination from the skin and draining lymph node. In t
he second set of experiments, i.m., local and combined antimonial regi
mens were compared. The local regimen, of 4 intralesional (i.l.) injec
tions of 4 mg of antimony at 5 d intervals, and the combined regimen (
i.m. and i.l.), were more efficient at clearing parasites than the sys
temic (i.m.) schedule, especially when a low dosage of Glucantime(R) (
30 mg/kg/d x 20 d) was used. The results suggest that combining local
treatment and low systemic dosages of antimonials results in clearance
of L. panamensis.