REDUCED BACTERIAL ADHESION TO HEPARIN-SURFACE-MODIFIED INTRAOCULAR LENSES

Bacterial adherence to intraocular lenses (IOLs) could be the cause of endophthalmitis following cataract surgery and lens implantation. The re are previous reports that heparin bound to the surface of poly(meth yl methacrylate) (PMMA) IOLs reduces cell adhesion. In this study, the in vitro adherence of Staphylococcus epidermidis, Staphylococcus aure us, and Pseudomonas aeruginosa to regular PMMA IOLs and to heparin-sur face-modified (HSM) PMMA IOLs was investigated. The three bacterial st rains attached in significantly lower numbers to HSM-PMMA IOLs than to PMMA IOLs (P <.01). Heparin in solution also inhibited attachment of Staphylococcus epidermidis to regular PMMA IOLs. Heparin may reduce ad herence by placing a highly hydrated layer between the bacteria and th e IOL surface. Therefore, the use of HSM-PMMA IOLs could diminish the incidence of endophthalmitis.