A NEURAL SHIFT THEORY OF MIGRAINE

Migraine headache may lend itself to epidemiological inquiry that incl udes disruptive serotonergic psychosocial behaviors. To advance our kn owledge of the etiology of this neurologic disorder, measurable psycho social behaviors that are correlated with variability in monoamine neu rotransmission need to be examined in the migraine population in a con trolled fashion. It may be that those with migraine have a more diffic ult time adapting to internal or external environmental changes based on a different distribution of serotonin levels or activity. Psychosoc ial behaviors are outlined as possible serotonin indicator variables f or future migraine investigation.