A broad overview is presented about the importance of molecular struct
ure determination and about the structural considerations that come in
view when molecular units build assemblies. Structural chemistry and
crystallography constitute an integral part of today's supramolecular
chemistry as demonstrated by various statements of giants of the field
. The challenge of supramolecular chemistry to the structural chemist
is in detecting and understanding the structural changes accompanying
molecular recognition and assembly formation and in providing assistan
ce for the design of new assemblies and molecular devices with desired
properties.