P. Veski et M. Marvola, SODIUM ALGINATES AS DILUENTS IN HARD GELATIN CAPSULES CONTAINING IBUPROFEN AS A MODEL-DRUG, Die Pharmazie, 48(10), 1993, pp. 757-760
The object of the study reported here was to investigate the effects o
f 14 grades of sodium alginate (Manugels(R) and Manucols(R)) on the di
ssolution of ibuprofen from hard gelatin capsules. Three drug: additiv
e ratios were investigated. Dissolution rates of each formulation foll
owed zero-order kinetics. The rate constants varied in the Manugel ser
ies from 5.8 to 19.4% . h-1 and in the Manucol series from 8.0 to 58.8
% . h-1. As a rule, the higher the viscosity grade of sodium alginate
the lower the rate of release of ibuprofen. However, rank order correl
ation was not perfect. Particle size also seemed to have some effect:
bigger particles gave less permeable gels.