INFLUENCE OF THE PREPARATION METHOD ON THE DISSOLUTION CHARACTERISTICS OF IBUPROFEN WITH LOW-MOLECULAR GELATIN

The effect of the preparation method on the dissolution characteristic s of ibuprofen (1)-low-molecular gelatin (LMG) solid mixtures has been studied. The 1-LMG solid mixtures in a weight ratio of 1:2 were prepa red by the kneading, grinding and co-precipitating methods and dissolu tion of these was carried out. The interaction of 1 with LMG in aqueou s solution and in the solid state was examined by solubility analysis, powder X-ray diffractometry and Differential Scanning Calorimetry (DS C) measurements. Also, the surface tension measurements of samples wer e performed. It was found that kneading and grinding methods were usef ul in increasing the dissolution rate of 1 from the solid mixtures whi ch were prepared by using LMG.