SYNTHESIS OF 7-HYDROXY-3-KETO-5-BETA-CHOLAN-24-OIC AND 12-HYDROXY-3-KETO-5-BETA-CHOLAN-24-OIC AND 7,12-DIHYDROXY-3-KETO-5-BETA-CHOLAN-24-OIC ACIDS BY REDUCTION OF 3,7-OXO, 3,12-OXO AND 3,7,12-OXO DERIVATIVES

Authors
FANTIN G FOGAGNOLO M MEDICI A PEDRINI P COVA U
Citation
G. Fantin et al., SYNTHESIS OF 7-HYDROXY-3-KETO-5-BETA-CHOLAN-24-OIC AND 12-HYDROXY-3-KETO-5-BETA-CHOLAN-24-OIC AND 7,12-DIHYDROXY-3-KETO-5-BETA-CHOLAN-24-OIC ACIDS BY REDUCTION OF 3,7-OXO, 3,12-OXO AND 3,7,12-OXO DERIVATIVES, Steroids, 58(11), 1993, pp. 524-526
Citations number
12
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
58
Issue
11
Year of publication
1993
Pages
524 - 526
Database
ISI
SICI code
0039-128X(1993)58:11<524:SO7A1>2.0.ZU;2-L
Abstract
7alpha-, 12alpha-, 12beta-Hydroxy and 7alpha,12alpha- and 7alpha,12bet a-dihydroxy-3-ketocholanoic acids were prepared in satisfactory yields protecting the 3-keto group as dimethyl ketal and subsequent reductio n with sodium borohydride of the corresponding 7- and 12-oxo functiona lities. The same procedure gave also 3,12-diketo-7alpha-hydroxy-cholan oic acid.