LARYNGO-ONYCHO-CUTANEOUS SYNDROME-ASSOCIATED WITH FAMILIAL BENIGN HYPERCALCEMIA

A Pakistani boy had chronic ulceration of the cheeks, generalized nail dystrophy, ulceration and hypergranulation of the nail beds, conjunct iva, and vocal cords, and dental enamel hypoplasia. These features are consistent with laryngo-onycho-cutaneous (LOCS) syndrome or Laryngeal and Ocular Granulation tissue in children from the Indian subContinen t (LOGIC) syndrome. Both he and his elder brother had elevated levels of serum calcium consistent with familial benign hypercalcemia. Laryng o-onycho-cutaneous syndrome is a newly recognized condition and its as sociation with familial benign hypercalcemia has not been previously r eported.