ENANTIOSPECIFIC HYDROLYSIS OF ESTERS OF NONSTEROIDAL ANTIINFLAMMATORYDRUGS USING LIPASE OF CANDIDA-CYLINDRACEA

Authors
DELCAMPO C GARCIA M GRADILLAS A LLAMA EF SALAZAR L SANCHEZMONTERO JM SINISTERRA JV
Citation
C. Delcampo et al., ENANTIOSPECIFIC HYDROLYSIS OF ESTERS OF NONSTEROIDAL ANTIINFLAMMATORYDRUGS USING LIPASE OF CANDIDA-CYLINDRACEA, Journal of molecular catalysis, 84(3), 1993, pp. 399-405
Citations number
21
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis → ACNP
ISSN journal
03045102
Volume
84
Issue
3
Year of publication
1993
Pages
399 - 405
Database
ISI
SICI code
0304-5102(1993)84:3<399:EHOEON>2.0.ZU;2-J
Abstract
Enantiospecific hydrolysis of esters of 2-arylpropionic acids with ant iinflammatory activity has been carried out. The racemic acids were sy nthetized by Willgerodt-Kindler synthesis in good yields. The enzymati c hydrolysis of the esters was carried out in a batch reactor with 0.2 M substrate concentration.