PREPARATION OF ALPHA,ALPHA-DIFLUORO-BETA-HYDROXY ESTERS VIA A MODIFIED REFORMATSKY REACTION

Authors
CURRAN TT
Citation
Tt. Curran, PREPARATION OF ALPHA,ALPHA-DIFLUORO-BETA-HYDROXY ESTERS VIA A MODIFIED REFORMATSKY REACTION, Journal of organic chemistry, 58(23), 1993, pp. 6360-6363
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
23
Year of publication
1993
Pages
6360 - 6363
Database
ISI
SICI code
0022-3263(1993)58:23<6360:POAEVA>2.0.ZU;2-R
Abstract
A modified Reformatsky reaction has been developed which allows for th e reproducible preparation of alpha,alpha-difluoro-beta-hydroxy- and g amma-amino-alpha,alpha-difluoro-beta-hydroxy esters in good yield from the corresponding aldehyde, ketone, or alpha-N-carbamoyl aldehyde.