CONFORMATIONAL-ANALYSIS OF 4,5-DIHYDRO-1-PHENYL-1H-2,4-BENZODIAZEPINES

Authors
SANNER MA JOSEF K JOHNSON RE DAMBRA T KOWALCZYK P KULLNIG RK MICHAELS F
Citation
Ma. Sanner et al., CONFORMATIONAL-ANALYSIS OF 4,5-DIHYDRO-1-PHENYL-1H-2,4-BENZODIAZEPINES, Journal of organic chemistry, 58(23), 1993, pp. 6417-6420
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
23
Year of publication
1993
Pages
6417 - 6420
Database
ISI
SICI code
0022-3263(1993)58:23<6417:CO4>2.0.ZU;2-O
Abstract
Detailed conformational analysis of 1-phenyl-1H-4,5-dihydro-2,4-benzod iazepines using X-ray structures, nuclear Overhauser experiments, vari able-temperature H-1 NMR, and MacroModel (MULTIC) reveals a rapid equi librium between axial and equatorial comformations for the free base o f 2. The DCl salt of 2 and 1-methyl-1-phenyl analog 3, however, prefer the axial conformation.