CLINICAL-STUDY ON THE THROMBOLYTIC EFFECT WITH DIFFERENT DOSES OF UROKINASE IN ACUTE MYOCARDIAL-INFARCTION

Objective To investigate the effects of different doses of intravenous domestic urokinase. Methods One thousand and twenty three cases of ac ute myocardial infarction within 6 hours after acute onset were divide d randomly into two groups with 539 cases in the low dose group (uroki nase 22 000IU/kg, total dose not lower than 1.2 million) and 484 in th e high dose group (30 000IU/kg, total dose not more than 2.4 million). The patency of infarct-related coronary artery was assessed by unifor m clinical criteria. Results In the low and high dose groups the paten cy rates were 67.3% and 67.8% respectively (P > 0.05); 4-week mortalit ies were 9.5% and 8.7% respectively (P > 0.05). Frequency of severe co mplications had no statistically significant difference between the tw o groups. Adverse bleeding was a little more frequent in the high than in the low dose group, and fatal cerebral hemorrhage in 2 cases occur red in the high dose group. Conclusion Low dose urokinase, 22 000 IU p er kg body weight with a total dose not lower than 1.2 million IU, is not only equally effective as high dose but also safer.