EFFECTS OF THROMBOLYTIC THERAPY ON RECANALIZATION IN DIFFERENT STARTING TIME OF TREATMENT AFTER ACUTE MYOCARDIAL-INFARCTION

Objective To investigate the effects of thrombolytic therapy on recana lization in different starting time of treatment after acute myocardia l infarction. Methods 172 cases with intravenous thrombolytic agents w ere divided into 4 groups: less than or equal to 2 hours, > 2-4 hours, > 4-6 hours and > 6-12 hours, according to the different starting tim e of therapy after onset of symptoms. Results The recanalization rates were 78.6%, 74%, 39.6%, and 14.3% in less than or equal to 2 hours, > 2-4 hours, > 4-6 hours and > 6-12 hours, respectively. The recanaliza tion rate within 4 hours was significantly higher than those in the gr oups of > 4-6 hours AND > 6 similar to 12 hours. The time interval fro m the initiation of thrombolytic therapy to reperfusion was increased as the starting lime of thrombolysis after onset of symptoms was delay ed. Conclusions Starting time of thrombolysis within 4 hours after ons et of acute myocardial infarction is of the best effect on recanalizat ion.