PREVALENCE OF FACTOR-V LEIDEN MUTATION IN NON-EUROPEAN POPULATIONS

A difference in the prevalence of venous thromboembolism (TE) in major human groups has been described and an uneven distribution of FV Leid en mutation over the world has recently been reported. We investigated FV Leiden mutation in 584 apparently healthy subjects mostly from pop ulations different from those previously investigated: 170 Europeans ( Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dend i), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa) , 84 Afroamericans (Rio Cayapa, Viche), and 57 Ethiopians (Amhara, Oro mo). The mutation was detected in only 1/115 Asian (Tharu) and in 5/17 0 Europeans (4 Italians, 1 Spanish). These data confirm that in non-Eu ropeans the prevalence of FV mutation is at least 7 times lower than i n Europeans and provide indirect evidence of a low prevalence not only of the FV Leiden gene but also of other genes leading to more severe thrombophilia. Finally, findings from the literature together with tho se pertaining to this study clearly show a marked heterogeneity among Europeans.