ACTIVITY OF THE ANTIOXIDANT SYSTEM OF RAT-LIVER UNDER BENZIDINE INTOXICATION AND AFTER ENOMELANIN ADMINISTRATION

Authors
LOMONOSOVA EE PIKULEV AT KURCHENKO VP
Citation
Ee. Lomonosova et al., ACTIVITY OF THE ANTIOXIDANT SYSTEM OF RAT-LIVER UNDER BENZIDINE INTOXICATION AND AFTER ENOMELANIN ADMINISTRATION, Biochemistry, 58(4), 1993, pp. 374-377
Citations number
21
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
58
Issue
4
Year of publication
1993
Pages
374 - 377
Database
ISI
SICI code
0006-2979(1993)58:4<374:AOTASO>2.0.ZU;2-U
Abstract
Benzidine administration in vivo decreased the efficiency of the prote ctive action of the antioxidant system. The total antioxidant activity of rat liver cytosol decreased along with superoxide dismutase and ca talase activities. Enomelanin promoted the restoration of superoxide d ismutase activity. These results suggest that the toxic effect of benz idine may be due to the impairment of the protective antioxidant mecha nisms of liver cells which control free radical-dependent processes.