EFFECT OF CALMODULIN ON THE ACTIVITY OF NAD-KINASE FROM RABBIT LIVER

Authors
BULYGINA ER VORONINA OL TELEPNEVA VI
Citation
Er. Bulygina et al., EFFECT OF CALMODULIN ON THE ACTIVITY OF NAD-KINASE FROM RABBIT LIVER, Biochemistry, 58(4), 1993, pp. 411-414
Citations number
24
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
58
Issue
4
Year of publication
1993
Pages
411 - 414
Database
ISI
SICI code
0006-2979(1993)58:4<411:EOCOTA>2.0.ZU;2-P
Abstract
Rabbit liver NAD-kinase is shown to be a Ca2+-dependent, calmodulin-re gulated enzyme. The sensitivities of the alpha- and beta-forms of the enzyme to calmodulin differ. The maximal activation of the alpha-form of the NAD-kinase was observed at a calmodulin/NAD-kinase ratio of 2, and that of the beta-form at 4. Further increase in this parameter (up to l0) had no effect on the activity of the alpha-form, whereas that of the beta-form dropped to the initial (basal) level.