THE ISOLATION OF LOVASTATIN AND ITS DETERMINATION BY DENSITOMETRIC TLC AND BY HPLC

Authors
KONFINO M DELTCHEVA S MINDJOVA K
Citation
M. Konfino et al., THE ISOLATION OF LOVASTATIN AND ITS DETERMINATION BY DENSITOMETRIC TLC AND BY HPLC, JPC. Journal of planar chromatography, modern TLC, 6(5), 1993, pp. 404-406
Citations number
4
Categorie Soggetti
Chemistry Analytical
Journal title
JPC. Journal of planar chromatography, modern TLC → ACNP
ISSN journal
09334173
Volume
6
Issue
5
Year of publication
1993
Pages
404 - 406
Database
ISI
SICI code
0933-4173(1993)6:5<404:TIOLAI>2.0.ZU;2-O
Abstract
Lovastatin is a fungal metabolite which has been found to be an active competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reduct ase (HMG-CoA reductase); as such it is a useful hypocholesterolemic an d hypolemic agent. The compound has been isolated from fermentation br oths of Aspergillus terreus: methods employing HPLC and densitometric TLC have been developed for controlling all steps of the isolation of lovastatin, both as the lactone and as the free hydroxy acid. The end product was closely examined and characterized.