Heparin-coated perfusion systems have been used to perform cardiopulmo
nary bypass with decreased systemic heparin dosages. We report the cas
e of a 60-year-old man with end-stage liver disease and severe aortic
stenosis who underwent an aortic valve replacement without systemic an
ticoagulation, employing a heparin-coated perfusion system. In patient
s with a contraindication to systemic anticoagulation, cardiopulmonary
bypass with a heparin-coated system without systemic anticoagulation
may be a viable alternative.