We examined changes in iron status in 25 female varsity collegiate swi
mmers over the course of a competitive season via weekly capillary blo
od sampling. We also studied the effectiveness of moderate iron supple
mentation (39 mg/day) in preventing expected changes in iron status vi
a a double-blinded crossover design. On entry into the study, 17 of th
e swimmers had depleted iron stores (plasma ferritin <12 mug/L) and 5
were anemic (Hb <120 g/L). After 5 wk of placebo treatment, hemoglobin
decreased (greater-than-or-equal-to 6 g/L) in 44% and increased in 12
% of the subjects. After 5 wk of iron supplementation, hemoglobin decr
eased in 16% and increased in 24% of the subjects. Likewise, after pla
cebo treatment, plasma ferritin decreased (greater-than-or-equal-to 5
mug/L) in 24% and increased in 4% of the subjects, whereas iron supple
mentation resulted in decreases in 4% and increases in 68% of the subj
ects. In the absence of iron supplementation, hemoglobin levels decrea
sed despite mean dietary iron intakes of 16.3 mg/day. These results sh
ow that moderate iron supplementation is effective in preventing decli
ne in the iron status of female collegiate swimmers during a competiti
ve season, but a higher dose of iron may be necessary to reverse their
iron-deficient state.