A STEREOSELECTIVE METHOD TO (E)-FLUOROVINYL AND (Z)-FLUOROVINYL PHOSPHONATES UTILIZING PALLADIUM(0) COUPLING METHODOLOGY

Authors
GROSS RS MEHDI S MCCARTHY JR
Citation
Rs. Gross et al., A STEREOSELECTIVE METHOD TO (E)-FLUOROVINYL AND (Z)-FLUOROVINYL PHOSPHONATES UTILIZING PALLADIUM(0) COUPLING METHODOLOGY, Tetrahedron letters, 34(45), 1993, pp. 7197-7200
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
45
Year of publication
1993
Pages
7197 - 7200
Database
ISI
SICI code
0040-4039(1993)34:45<7197:ASMT(A>2.0.ZU;2-X
Abstract
The first stereoselective method to both (E)- and (Z)-fluorovinyl phos phonates from fluorovinyl iodides was developed utilizing a palladium( 0) based coupling protocol. This method allowed the preparation of (E) - and (Z)-fluorovinyl phosphonic acid analogs of glucose-6-phosphate t hat were designed to be mechanism-based inhibitors of inositol synthas e.