L. Campayo et al., SYNTHESIS OF A STABLE DINUCLEAR COMPLEX FORMED FROM A 26 MEMBERED PROTON-IONIZABLE CROWN OF 3,5-DISUSBSTITUTED 1H-PYRAZOLE AND HOMOVERATRYLAMINE, Tetrahedron letters, 34(45), 1993, pp. 7299-7300
The 26 membered proton ionizable crown of 3,5-disubstituted 1H-pyrazol
e 1 acts as a synthetic receptor able to interac with the amino group
common to neurotransmitter substrates, such as catecholamines. The syn
thesis of a solid and stable dinuclear complex formed by proton ioniza
ble crown 1 and homoveratrylamine is described. The FAB mass spectrum
of complex, and the differences found in C-13-RMN spectra of crown 1 a
nd its dinuclear complex 3 are commented. The isolation of this dinucl
ear complex confirm the hypothesis that of synthetic receptor 1 is abl
e to recognise catecholamines and to interact with the amno group of s
uch amines.