S. Isaacs et al., PETROSYNOL AND PETROSOLIC ACID, 2 NOVEL NATURAL INHIBITORS OF THE REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS FROM PETROSIA SP, Tetrahedron, 49(45), 1993, pp. 10435-10438
Two potyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1
), and the novel marine natural product petrosolic acid (2) were found
effective in inhibitory of the DNA polymerase activities of the rever
se transcriptase of human immunodeficiency virus. The structure of com
pound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid w
as determined mainly by NMR spectroscopy.