PETROSYNOL AND PETROSOLIC ACID, 2 NOVEL NATURAL INHIBITORS OF THE REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS FROM PETROSIA SP

Authors
ISAACS S KASHMAN Y LOYA S HIZI A LOYA Y
Citation
S. Isaacs et al., PETROSYNOL AND PETROSOLIC ACID, 2 NOVEL NATURAL INHIBITORS OF THE REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS FROM PETROSIA SP, Tetrahedron, 49(45), 1993, pp. 10435-10438
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
45
Year of publication
1993
Pages
10435 - 10438
Database
ISI
SICI code
0040-4020(1993)49:45<10435:PAPA2N>2.0.ZU;2-G
Abstract
Two potyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1 ), and the novel marine natural product petrosolic acid (2) were found effective in inhibitory of the DNA polymerase activities of the rever se transcriptase of human immunodeficiency virus. The structure of com pound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid w as determined mainly by NMR spectroscopy.