Rl. Roof et al., GENDER-SPECIFIC IMPAIRMENT ON MORRIS WATER MAZE TASK AFTER ENTORHINALCORTEX LESION, Behavioural brain research, 57(1), 1993, pp. 47-51
After unilateral entorhinal cortex lesion, deficits on a working spati
al memory Morris water maze task were examined in male and female rats
to determine if gender differences exist in response to hippocampal d
eafferentation. Brain-damaged males showed a persistent water maze def
icit that persisted throughout the 10 days of testing. Brain-damaged f
emales did not. The performance of the injured females was only slight
ly impaired relative to sham males and females, and was significantly
better than males with EC damage. This lack of a water maze deficit in
lesion females is hypothesized to be due either to gender differences
in sprouting responses or to a more flexible use of multiple cues by
females relative to males.