PROTECTIVE EFFECT OF IRIDALS FROM SAPONIN INJURY IN CANDIDA-ALBICANS CELLS

Citation
O. Leconte et al., PROTECTIVE EFFECT OF IRIDALS FROM SAPONIN INJURY IN CANDIDA-ALBICANS CELLS, Phytochemistry, 44(4), 1997, pp. 575-579
Citations number
28
Categorie Soggetti
Plant Sciences
Journal title
ISSN journal
00319422
Volume
44
Issue
4
Year of publication
1997
Pages
575 - 579
Database
ISI
SICI code
0031-9422(1997)44:4<575:PEOIFS>2.0.ZU;2-0
Abstract
Spirostanol saponin permeabilization of Candida albicans cells resulte d in phosphate (Pi) leakage from these cells. Pre-incubation of C. alb icans suspension cultures with ergosterol or cycloiridals inhibited Pi leakage when cells were subjected to saponins. Saponins were shown to precipitate ergosterol but not cycloiridals. Inhibition of Pi leakage in the presence of cycloiridals could thus be due to their incorporat ion into cell membranes. Cycloiridals, which were previously shown to modify fluidity parameters in artificial phospholipid bilayers, seem i n vivo to have a protective effect on membranes against surfactant (sa ponin) injury. Copyright (C) 1997 Elsevier Science Ltd.