BIOTRANSFORMATION OF THE GERMACRANE TYPE SESQUITERPENE CURDIONE BY SUSPENSION-CULTURED CELLS OF LONICERA-JAPONICA

Curdione, a sesquiterpene with a germacrane skeleton, was incubated wi th suspension cultured cells induced from calli of Lonicera japonica f or 10 days. The ethyl acetate-soluble fraction of the culture medium g ave a number of products, of which six were shown to be (2S)-2-hydroxy curdione, (2R)-2-hydroxycurdione, (8S)-6-hydroxycurdione, (2R, 8S)-8-h ydro-2-hydroxycurdione, (1S, 10S)-1,10-epoxycurdione and (1R, 10R)-1.1 0-epoxycurdione, respectively. Copyright (C) 1997 Elsevier Science Ltd .