PHOSPHOCITRATE PREVENTS DISEASE PROGRESSION IN MURINE PROGRESSIVE ANKYLOSIS

Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progre ssive ankylosis (matched for age, weight, and sex) were treated parent erally for 6 weeks with either PC or saline vehicle. Results. Clinical ly, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice. Conclusion. PC appears to inhibit disease pro gression in murine progressive ankylosis.