EFFECTS OF THYMUS HUMORAL FACTOR-GAMMA-2 (THF-GAMMA-2) ON LYMPHOHAEMATOPOIETIC PROGENITOR CELLS - AN IN-VITRO STUDY

Authors
CALENDA V SILVY F CHERMANN JC
Citation
V. Calenda et al., EFFECTS OF THYMUS HUMORAL FACTOR-GAMMA-2 (THF-GAMMA-2) ON LYMPHOHAEMATOPOIETIC PROGENITOR CELLS - AN IN-VITRO STUDY, Research in immunology, 144(6-7), 1993, pp. 395-406
Citations number
17
Categorie Soggetti
Immunology
Journal title
Research in immunology → ACNP
ISSN journal
09232494
Volume
144
Issue
6-7
Year of publication
1993
Pages
395 - 406
Database
ISI
SICI code
0923-2494(1993)144:6-7<395:EOTHF(>2.0.ZU;2-S
Abstract
Thymus humoral factor gamma-2 (THFgamma2), an immunomodulatory factor, was previously shown to exert a regulatory effect upon human haematop oietic development. In the present study, we were primarily interested in determining whether THFgamma2 has an immunorestorative effect afte r HIV infection. Although no inhibition of viral production by T-clust er-forming cells and their mature progeny was observed, this thymus-de rived compound prevented the dramatic decrease in CD4+ cells observed in cultures of immature T cells from normal bone marrow infected with HIV1.