BACKGROUND Intermediate uveitis is characterized by vitreal inflammati
on with associated inflammation of the vitreous base and peripheral an
terior retina and choroid. It may be found as an isolated and idiopath
ic condition or in association with systemic disorders such as multipl
e sclerosis and sarcoidosis. OBJECTIVE To identify the clinical featur
es of intermediate uveitis and assess its association with systemic di
seases. METHODS Retrospective study of 83 patients presenting with int
ermediate uveitis between 1970 and 1991. RESULTS Evidence of systemic
disorders was found in 26 of 83 patients (31.3%). Of these 26 patients
, 10 had presumed sarcoidosis, 6 had multiple sclerosis, 2 had isolate
d optic neuritis, 2 had inflammatory bowel disease, 4 had isolated thy
roid abnormalities, and 2 had histories suggestive of Epstein-Barr vir
us infection. Associated ocular findings included cystoid macular edem
a, peripheral retinal perivascular sheathing, cataracts, posterior vit
reous detachment, fine keratic precipitates, preretinal macular fibros
is, retinal tears, retinal detachment, and optic disc edema. CONCLUSIO
NS Patients with intermediate uveitis may have associated systemic dis
eases and should have careful follow-up with regular systemic evaluati
on.