DIFFERENTIAL IMMUNOCYTOCHEMICAL LOCALIZATION OF GABA(A) RECEPTOR GAMMA(1) AND RECEPTOR GAMMA(2) SUBUNITS IN THE RAT-BRAIN

Authors
ARAKI T KIYAMA H MAENO H TOHYAMA M
Citation
T. Araki et al., DIFFERENTIAL IMMUNOCYTOCHEMICAL LOCALIZATION OF GABA(A) RECEPTOR GAMMA(1) AND RECEPTOR GAMMA(2) SUBUNITS IN THE RAT-BRAIN, Molecular brain research, 20(3), 1993, pp. 263-266
Citations number
29
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
20
Issue
3
Year of publication
1993
Pages
263 - 266
Database
ISI
SICI code
0169-328X(1993)20:3<263:DILOGR>2.0.ZU;2-X
Abstract
Subunit-specific polyclonal antisera against the GABA(A) receptor gamm a1 and gamma2 subunits were raised in rabbits and used for immunoblott ing and immunocytochemistry of the rat brain. Each subunit protein was differentially distributed even in the region like cerebellar cortex where mRNAs of both subunits were distributed in the same manner. This may indicate that GABA(A) receptor gamma1 and gamma2 subunit proteins are subject to a subunit-specific subcellular sorting mechanism.